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Association between bone mineral density and type 1 diabetes mellitus: a meta‐analysis of cross‐sectional studies
Author(s) -
Pan Hong,
Wu Naping,
Yang Tao,
He Wei
Publication year - 2014
Publication title -
diabetes/metabolism research and reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.307
H-Index - 110
eISSN - 1520-7560
pISSN - 1520-7552
DOI - 10.1002/dmrr.2508
Subject(s) - medicine , bone mineral , meta analysis , type 1 diabetes , confidence interval , cross sectional study , diabetes mellitus , femur , endocrinology , osteoporosis , surgery , pathology
Summary A few studies have investigated the relationship between type 1 diabetes mellitus (T1DM) and bone mineral density (BMD) values. This meta‐analysis was performed to explore differences between T1DM and healthy individuals in BMD values measured at five bone sites.We searched the database of PubMed for cross‐sectional studies about the association of T1DM and BMD, and a meta‐analysis was conducted.The results suggested significant association between T1DM and decreased BMD values of total body. The pooled mean differences (MDs) were −0.06 [95% confidence interval (CI): −0.11, −0.01] for all people. As for the association between T1DM and spine BMD values, the pooled MDs were −0.04 (95% CI: −0.07, −0.01) for males and −0.03 (95% CI: −0.06, 0.00) for females <20 years old. As for femur BMD values, the pooled MDs were −0.06 (95% CI: −0.13, 0.00) for all people, −0.03 (95% CI: −0.06, −0.01) for females and −0.04(95% CI: −0.05, −0.02) for males. As for hip BMD values, the pooled MDs were −0.06 (95% CI: −0.08, −0.04) for females. As for forearm BMD values, the pooled MDs were −0.01 (95% CI: −0.02, 0.00) for females.The results of this meta‐analysis suggest the overall association between T1DM and reduced BMD values. Notably, the influence of T1DM on BMD seems to depend on gender or patient's age. Reduced BMD values may occur early after T1DM diagnosis. Future clinical and basic research studies are needed to further understand the mechanisms of decreased BMD values in T1DM patients. Copyright © 2013 John Wiley & Sons, Ltd.