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Steroid‐induced diabetes: a clinical and molecular approach to understanding and treatment
Author(s) -
Hwang Jessica L.,
Weiss Roy E.
Publication year - 2014
Publication title -
diabetes/metabolism research and reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.307
H-Index - 110
eISSN - 1520-7560
pISSN - 1520-7552
DOI - 10.1002/dmrr.2486
Subject(s) - diabetes mellitus , medicine , intensive care medicine , glucocorticoid , limiting , adverse effect , bioinformatics , disease , endocrinology , biology , mechanical engineering , engineering
Summary Since the advent of glucocorticoid therapy for autoimmune disease in the 1940s, their widespread application has led to the concurrent therapy‐limiting discovery of many adverse metabolic side effects. Unanticipated hyperglycemia associated with the initiation of glucocorticoids often leads to preventable hospital admissions, prolonged hospital stays, increased risks for infection and reduced graft function in solid organ transplant recipients. Challenges in managing steroid‐induced diabetes stem from wide fluctuations in post‐prandial hyperglycemia and the lack of clearly defined treatment protocols. The mainstay of treatment is insulin therapy coincident with meals. This article aims to review the pathogenesis, risk factors, diagnosis and treatment principles unique to steroid‐induced diabetes. Copyright © 2013 John Wiley & Sons, Ltd.