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Early postnatal growth in children with HLA‐conferred susceptibility to type 1 diabetes
Author(s) -
Peet A.,
Hämäläinen A.M.,
Kool P.,
Ilonen J.,
Knip M.,
Tillmann V.
Publication year - 2014
Publication title -
diabetes/metabolism research and reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.307
H-Index - 110
eISSN - 1520-7560
pISSN - 1520-7552
DOI - 10.1002/dmrr.2449
Subject(s) - demography , relative risk , type 1 diabetes , medicine , genotype , human leukocyte antigen , diabetes mellitus , obesity , disease , incidence (geometry) , estonian , pediatrics , biology , endocrinology , immunology , genetics , confidence interval , antigen , sociology , gene , linguistics , philosophy , physics , optics
Aims/Hypothesis An association between increased length/height and weight gain and risk of type 1 diabetes (T1D) has been reported in children. We set out to investigate the potential contribution of T1D human leukocyte antigen (HLA) risk genotypes to this association in two countries with a contrasting disease incidence. Methods In Estonia and Finland, length and weight were monitored up to the age of 24 months in 688 subjects. According to their HLA genotypes, the children were divided into four groups, those with very high, high or moderate risk for T1D, as well as a neutral/control group. Relative length and weight (SDS) were assessed and compared at 3, 6, 12, 18 and 24 months using World Health Organization (WHO) growth curves. Results The mean relative length at the age of 24 months was lower in the group with the very high risk HLA genotype compared to the controls ( p < 0.05). The mean relative weight differed between those two groups at the age of 12, 18 and 24 months ( p < 0.05). When Estonian and Finnish cohorts were analyzed separately, the relative length showed similar but non‐significant trends in both countries, while in Estonia the changes in weight at some time points still remained significant ( p < 0.05). Conclusions Children with the highest HLA‐conferred risk for T1D gained less weight and length during the first 24 months of life, and this feature was more pronounced in the Estonian children. Copyright © 2013 John Wiley & Sons, Ltd.