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AdipoQ polymorphisms are associated with type 2 diabetes mellitus: a meta‐analysis study
Author(s) -
Chu Haiyan,
Wang Meilin,
Zhong Dongyan,
Shi Danni,
Ma Lan,
Tong Na,
Zhang Zhengdong
Publication year - 2013
Publication title -
diabetes/metabolism research and reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.307
H-Index - 110
eISSN - 1520-7560
pISSN - 1520-7552
DOI - 10.1002/dmrr.2424
Subject(s) - adiponectin , meta analysis , publication bias , odds ratio , confidence interval , funnel plot , medicine , type 2 diabetes mellitus , allele , genetic model , type 2 diabetes , diabetes mellitus , endocrinology , genetics , biology , gene , obesity , insulin resistance
Objective Adiponectin (AdipoQ) plays an important role in the pathogenesis of diabetes mellitus and is considered as an important candidate gene for type 2 diabetes mellitus (T2DM). So far, there have been many studies to investigate the association between the adiponectin polymorphisms and T2DM risk. However, the results are conflicting. To derive a more precise estimation, we performed a meta‐analysis to assess the association between five AdipoQ polymorphisms [−11426A > G (rs16861194), −11391G > A (rs17300539), −11377C > G (rs266729), +45T > G (rs2241766) and +276G > T (rs1501299)], and T2DM risk. Methods The fixed and random‐effects model should be used to assess the summary odds ratios (ORs) of each study. ORs with 95% confidence intervals (CIs) were used to evaluate the strength of association. On the basis of the included criteria, we selected 39 papers, among which eight for −11426A > G, 14 for −11391G > A, 21 for −11377C > G, 28 for +45 T > G and 24 for +276G > T. Sensitivity analyses were conducted to assess the stability of the results. Both Begg's funnel plots and Egger's test are commonly used to evaluate publication bias. Results Overall, we found that individuals with the −11426G allele had a 0.15‐fold significantly increased T2DM risk (additive model: 1.15, 1.04–1.27, 0.222). In the stratified analyses, we found that the −11426A > G, −11391G > A and −11377C > G polymorphisms could increase T2DM risk in European populations in the additive model. For Asian populations, we found that the −11377C > G polymorphism also could elevate T2DM risk. Conclusions Our results suggested that the adiponectin −11426A > G polymorphism could contribute to the T2DM risk. Copyright © 2013 John Wiley & Sons, Ltd.