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The COBLL1 C allele is associated with lower serum insulin levels and lower insulin resistance in overweight and obese children
Author(s) -
Mancina Rosellina Margherita,
Burza Maria Antonella,
Maglio Cristina,
Pirazzi Carlo,
Sentinelli Federica,
Incani Michela,
Montalcini Tiziana,
Pujia Arturo,
Congiu Tiziana,
Loche Sandro,
Pilia Sabrina,
Wiklund Olov,
Borén Jan,
Romeo Stefano,
Baroni Marco Giorgio
Publication year - 2013
Publication title -
diabetes/metabolism research and reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.307
H-Index - 110
eISSN - 1520-7560
pISSN - 1520-7552
DOI - 10.1002/dmrr.2408
Subject(s) - insulin resistance , overweight , insulin , medicine , endocrinology , obesity , allele , biology , gene , genetics
Abstract Background Childhood obesity is a growing epidemic worldwide, and it is associated with metabolic complications, such as insulin resistance. Recently, a genetic variation (rs7607980) in the COBLL1 gene has been associated with lower insulin resistance in adults. The aim of the study was to investigate if the association between COBLL1 rs7607980 genetic variant and lower insulin resistance was present early in life. Methods This sequence variant was genotyped in 878 overweight and obese children (mean age: 10 years) from Sardinia, Italy, from the outpatient clinic of the Pediatric Endocrine Unit, at the Regional Hospital for Microcitaemia in Cagliari. Insulin resistance was assessed by measurement of fasting circulating insulin levels before and after an oral glucose tolerance test and by HOMA‐IR. Results The COBLL1 rs7607980 C allele was associated with lower fasting insulin and HOMA‐IR levels ( p = 0.002 and p = 0.035, respectively) in overweight and obese children. Importantly, lower insulin levels were also observed 2 h after oral glucose tolerance test in C allele carriers ( p = 0.009). Conclusions The present study shows for the first time, the association between COBLL1 rs7607980 C allele, lower serum insulin levels and lower insulin resistance in overweight and obese children. Copyright © 2013 John Wiley & Sons, Ltd.