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The role of glycogen synthase in the development of hyperglycemia in type 2 diabetes – ‘To store or not to store glucose, that's the question’
Author(s) -
BeckNielsen Henning
Publication year - 2012
Publication title -
diabetes/metabolism research and reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.307
H-Index - 110
eISSN - 1520-7560
pISSN - 1520-7552
DOI - 10.1002/dmrr.2337
Subject(s) - glycogen , endocrinology , glycogen synthase , context (archaeology) , medicine , diabetes mellitus , enzyme , insulin resistance , type 2 diabetes , gsk 3 , skeletal muscle , glycogen storage disease , biology , chemistry , biochemistry , phosphorylation , paleontology
Summary This review deals with the role of glycogen storage in skeletal muscle for the development of insulin resistance and type 2 diabetes. Specifically, the role of the enzyme glycogen synthase, which seems to be locked in its hyperphosphorylated and inactivated state, is discussed. This defect seems to be secondary to ectopic lipid disposition in the muscle cells. These molecular defects are discussed in the context of the overall pathophysiology of hyperglycemia in type 2 diabetic subjects. Copyright © 2012 John Wiley & Sons, Ltd.