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Evaluation of weight loss and adipocytokines levels after two hypocaloric diets with different macronutrient distribution in obese subjects with rs9939609 gene variant
Author(s) -
Luis Daniel Antonio,
Aller Rocío,
Izaola Olatz,
Fuente Beatriz,
Conde Rosa,
Sagrado Manuel Gonzalez,
Primo David
Publication year - 2012
Publication title -
diabetes/metabolism research and reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.307
H-Index - 110
eISSN - 1520-7560
pISSN - 1520-7552
DOI - 10.1002/dmrr.2323
Subject(s) - medicine , endocrinology , adipokine , weight loss , obesity , waist , leptin , glucose homeostasis , genotype , body mass index , insulin resistance , biology , gene , genetics
Background Common polymorphisms of the fat mass and obesity associated gene (FTO) have been linked to obesity in some populations. One of these genetic variants (rs9939609) has been related to an increased risk of obesity. Objective Our aim was to evaluate weight loss and adipocytokine levels after two hypocaloric diets with different macronutrient distribution in obese subjects with RS9939609 gene variant. Design 305 obese patients were enrolled in a prospective way. In the basal visit, patients were randomly allocated during 3 months to low carbohydrates and low fat. Results After treatment with both diets and in both genotypes, weight, fat mass, waist circumference and systolic blood pressures decreased. With the diet type I and in TT genotype, insulin (−6.6 ± 9.8 IU/L) and homeostasis model assessment (−2.9 ± 6.1 units) decreased. With the diet type II and in both genotypes (wild and mutant type), insulin (−5.2 ± 6.1 vs . −3.8 ± 6.1 IU/L; p < 0.05) and homeostasis model assessment (−2.4 ± 4.8 vs . −1.1 ± 3.8 kg; p < 0.05) decreased. In the A allele group, a significant decrease was detected in total cholesterol levels (−11.5 ± 20.1 mg/dL), low density lipoprotein cholesterol levels (−13.2 ± 20.9 mg/dL) and c‐reactive protein levels (−1.3 ± 3.8 mg/dL) secondary to weight loss after treatment with diet II. The decrease of leptin levels was higher in mutant type group than wild type group with low fat diet (−10.3 ± 36.1 vs . −28.6 ± 53.7 ng/mL; p < 0.05). Conclusion Metabolic improvement secondary to weight loss was better in A carriers with a low fat hypocaloric diet. Copyright © 2012 John Wiley & Sons, Ltd.