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Adipokines and metabolic syndrome risk factors in women with previous gestational diabetes mellitus
Author(s) -
RocaRodríguez M. Mar,
LópezTinoco Cristina,
FernándezDeudero Álvaro,
Murri Mora,
GarcíaPalacios María Victoria,
GarcíaValero M. Amor,
TinahonesMadueño Francisco J.,
AguilarDiosdado Manuel
Publication year - 2012
Publication title -
diabetes/metabolism research and reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.307
H-Index - 110
eISSN - 1520-7560
pISSN - 1520-7552
DOI - 10.1002/dmrr.2313
Subject(s) - gestational diabetes , medicine , metabolic syndrome , adiponectin , adipokine , endocrinology , body mass index , diabetes mellitus , insulin resistance , uric acid , waist , pregnancy , gestation , biology , genetics
Background Gestational diabetes mellitus (GDM) has been recognized as a significant risk factor for metabolic syndrome and CVD. The aim of the study was to evaluate the relationships between levels of cytokines, components of metabolic syndrome and cardiovascular risk markers in women with previous gestational diabetes. Methods Women ( n = 41) with gestational diabetes background (cases) and 21 healthy women (controls) in the postpartum period were enrolled. Demographic and clinical data, lipid and carbohydrate metabolism and uric acid and adipokine levels (TNF‐α, IL‐6, leptin and adiponectin) were compared and their relationships analysed. Metabolic syndrome prevalence was calculated by WHO and NCEP‐ATPIII definitions. Results There were significant differences between cases and controls: body mass index (kg/m 2 ) 27.4 ± 5.6 vs 23.9 ± 3.6 ( p = 0.013), waist circumference (cm) 85.2 ± 12.9 vs 77.5 ± 9.0 ( p = 0.017), metabolic syndrome (WHO definition) 14.6% vs 0% ( p = 0.012), metabolic syndrome (NCEP‐ATPIII definition) 22% vs 0% ( p = 0.002), low HDL 36.6% vs 9.5% ( p = 0.024), fasting glucose (mmol/L) 5.4 ± 0.6 vs 4.9 ± 0.2 ( p < 0.001), glucose 120′ oral glucose tolerance test (mmol/L) 5.8 ± 1.7 vs 4.7 ± 0.8 ( p = 0.007), fasting insulin (μU/mL) 13.4 ± 8.1 vs 8.4 ± 4.3 ( p = 0.004), HOMA index 3.3 ± 2.3 vs 1.8 ± 1.0 ( p = 0.002), HbA 1c (%) 5.4 ± 0.2 vs 5.2 ± 0.2 ( p = 0.021), uric acid (mg/dL) 4.1 ± 1 vs 3.5 ± 0.6 ( p = 0.009), leptin (ng/mL) 32 025.5 ± 19 917.3 vs 20 258.9 ± 16 359.9 ( p = 0.023), respectively. Conclusions Women with previous gestational diabetes have central adiposity, atherogenic lipid profile, carbohydrate intolerance and adverse adipokine profile, all of which are risk factors for the future development of metabolic disease and CVD. Copyright © 2012 John Wiley & Sons, Ltd.