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Hemoglobin variants and determination of glycated hemoglobin (HbA 1c )
Author(s) -
Schnedl Wolfgang J.,
Liebminger Andrea,
Roller Regina E.,
Lipp Rainer W.,
Krejs Guenter J.
Publication year - 2001
Publication title -
diabetes/metabolism research and reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.307
H-Index - 110
eISSN - 1520-7560
pISSN - 1520-7552
DOI - 10.1002/dmrr.186
Subject(s) - glycated hemoglobin , united kingdom prospective diabetes study , glycemic , medicine , diabetes mellitus , hemoglobin , hemoglobin variants , type 2 diabetes , endocrinology
Measurement of glycated hemoglobin in diabetic patients is an established procedure for evaluating long‐term control of diabetes. The Diabetes Control and Complications Trial (DCCT), as well as the United Kingdom Prospective Diabetes Study (UKPDS), confirmed the direct relationship between the degree of glycemic control as estimated by glycohemoglobin (GHb) determinations and the development and progression of long‐term complications in diabetic patients. Samples with known interferences of HbA 1c determination as hemoglobinopathies are specifically excluded from certification testing and there are no guidelines or requirements for comparability of samples containing hemoglobin (Hb) variants. This paper reviews the interference of Hb variants on determination methods of glycated hemoglobin as they result in false HbA 1c results. Copyright © 2001 John Wiley & Sons, Ltd.