Premium
Methods of investigation for cardiac autonomic dysfunction in human research studies
Author(s) -
Bernardi Luciano,
Spallone Vincenza,
Stevens Martin,
Hilsted Jannik,
Frontoni Simona,
PopBusui Rodica,
Ziegler Dan,
Kempler Peter,
Freeman Roy,
Low Phillip,
Tesfaye Solomon,
Valensi Paul
Publication year - 2011
Publication title -
diabetes/metabolism research and reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.307
H-Index - 110
eISSN - 1520-7560
pISSN - 1520-7552
DOI - 10.1002/dmrr.1224
Subject(s) - medicine , baroreflex , autonomic function , heart rate variability , autonomic neuropathy , autonomic nervous system , intensive care medicine , heart rate , neuroscience , blood pressure , psychology , biology , genetics , cell culture , neuroblastoma
This consensus document provides evidence‐based guidelines regarding the evaluation of diabetic cardiovascular autonomic neuropathy (CAN) for human research studies; the guidelines are the result of the work of the CAN Subcommittee of the Toronto Diabetic Neuropathy Expert Group. The subcommittee critically reviewed the limitations and strengths of the available diagnostic approaches for CAN and the need for developing new tests for autonomic function. It was concluded that the most sensitive and specific approaches currently available to evaluate CAN in clinical research are: (1) heart rate variability, (2) baroreflex sensitivity, (3) muscle sympathetic nerve activity, (4) plasma catecholamines, and (5) heart sympathetic imaging. It was also recommended that efforts should be undertaken to develop new non‐invasive and safe CAN tests to be used in clinical research, with higher sensitivity and specificity, for studying the pathophysiology of CAN and evaluating new therapeutic approaches. Copyright © 2011 John Wiley & Sons, Ltd.