Genome‐wide association studies (GWAS): impact on elucidating the aetiology of diabetes | Zendy

Hakonarson Hakon | Zendy; Grant Struan F. A. | Zendy

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Genome‐wide association studies (GWAS): impact on elucidating the aetiology of diabetes

Author(s) -

Hakonarson Hakon,

Grant Struan F. A.

Publication year - 2011

Publication title -

diabetes/metabolism research and reviews

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.307

H-Index - 110

eISSN - 1520-7560

pISSN - 1520-7552

DOI - 10.1002/dmrr.1221

Subject(s) - genome wide association study , context (archaeology) , genetic association , type 2 diabetes , disease , complex disease , biology , computational biology , genetics , bioinformatics , diabetes mellitus , medicine , gene , single nucleotide polymorphism , genotype , paleontology , endocrinology

It has proven to be challenging to isolate the genes underlying the genetic components conferring susceptibility to type 1 and type 2 diabetes. Unlike previous approaches, ‘genome‐wide association studies’ have extensively delivered on the promise of uncovering genetic determinants of complex diseases, with a number of novel disease‐associated variants being largely replicated by independent groups. This review provides an overview of these recent breakthroughs in the context of type 1 and type 2 diabetes, and outlines strategies on how these findings will be applied to impact clinical care for these two highly prevalent disorders. Copyright © 2011 John Wiley & Sons, Ltd.

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