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The changing epidemiology of type 1 diabetes: why is it going through the roof?
Author(s) -
Vehik Kendra,
Dabelea Dana
Publication year - 2011
Publication title -
diabetes/metabolism research and reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.307
H-Index - 110
eISSN - 1520-7560
pISSN - 1520-7552
DOI - 10.1002/dmrr.1141
Subject(s) - incidence (geometry) , epidemiology , disease , type 2 diabetes , environmental health , medicine , biology , diabetes mellitus , pathology , physics , optics , endocrinology
The incidence of type 1 diabetes is increasing and this may double the burden of disease in our youngest by 2020. The recent increase in incidence is mostly happening in the very young and those with moderate genetic susceptibility. Many environmental factors have been implicated, but no major determinants have been clearly identified, and the mechanisms of involvement remain elusive. This review summarizes current research efforts directed at understanding the possible reasons for this increase, including the role of viruses, gut microbiota, early life feeding patterns, perinatal factors and childhood growth patterns. It also provides a road map for future research directions. Copyright © 2010 John Wiley & Sons, Ltd.