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Evolution and predictors of morphological and functional arterial changes in the course of type 1 diabetes mellitus
Author(s) -
Vastagh Ildikó,
Horváth Tamás,
Nagy Géza,
Varga Tímea,
Juhász Eszter,
Juhász Viktória,
Kollai Márk,
Bereczki Dániel,
Somogyi Anikó
Publication year - 2010
Publication title -
diabetes/metabolism research and reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.307
H-Index - 110
eISSN - 1520-7560
pISSN - 1520-7552
DOI - 10.1002/dmrr.1133
Subject(s) - pulse wave velocity , medicine , diabetes mellitus , type 2 diabetes mellitus , arterial stiffness , cardiology , body mass index , applanation tonometry , intima media thickness , carotid arteries , endocrinology , blood pressure
Abstract Background Diabetes mellitus results in accelerated atherosclerosis. We evaluated preclinical, morphological and functional vascular changes in type 1 diabetes mellitus. Methods Diameter, intima‐media thickness, intima‐media cross‐section area, and elasticity features (compliance, distensibility coefficient, circumferential strain, stiffness index, incremental elastic modulus) of the common carotid arteries and carotid‐femoral pulse wave velocity were studied in 42 patients with type 1 diabetes mellitus without macroangiopathy, and 41 control subjects matched for sex, age and body mass index using an ultrasonographic vessel wall‐movement tracking system and applanation tonometry. Results Significantly larger intima‐media thickness (523 ± 55 versus 567 ± 89 µm, p < 0.01), intima‐media cross‐section area (11.60 ± 1.81 versus 13.08 ± 3.02 mm 2 , p < 0.01), SI (5.58 ± 1.24 versus 7.08 ± 2.69, p < 0.01) and pulse wave velocity (6.00 ± 0.82 versus 6.61 ± 1.56 m/s, p < 0.05) were found in type 1 diabetes mellitus patients compared to controls. When type 1 diabetes mellitus patients with short and long disease duration (≤ or > 10 years) were compared, diameter (6450 ± 433 versus 6847 ± 750 µm, p < 0.05), intima‐media cross‐section area (11.97 ± 1.98 versus 14.01 ± 3.43 mm, p < 0.05) and pulse wave velocity (5.90 ± 0.92 versus 7.20 ± 1.74 m/s, p < 0.01) differed significantly. When multivariate analyses were restricted to type 1 diabetes mellitus patients, age was an independent predictor of stiffness index and pulse wave velocity, the duration of diabetes mellitus of intima‐media cross‐section area and pulse wave velocity, systolic blood pressure of diameter and pulse wave velocity, and low‐density lipoprotein‐cholesterol of intima‐media thickness, intima‐media cross‐section area and stiffness index. Conclusions There are differences in the time course of evolution and in predictors of morphological and functional changes in arteries in type 1 diabetes mellitus. Copyright © 2010 John Wiley & Sons, Ltd.