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Association of the fatty acid‐binding protein 2 gene Ala54Thr polymorphism with insulin resistance and blood glucose: a meta‐analysis in 13451 subjects
Author(s) -
Zhao Tongfeng,
Zhao Jiangpei,
Yang Wanxi
Publication year - 2010
Publication title -
diabetes/metabolism research and reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.307
H-Index - 110
eISSN - 1520-7560
pISSN - 1520-7552
DOI - 10.1002/dmrr.1085
Subject(s) - insulin resistance , medicine , insulin , glucose homeostasis , endocrinology , meta analysis , confidence interval , biology , genetic model , allele , quantitative insulin sensitivity check index , homeostatic model assessment , genetics , gene , insulin sensitivity
Background The results from the published studies on the association of fatty acid‐binding protein 2 (FABP2) Ala54Thr polymorphism with insulin resistance and blood glucose are conflicting. In this meta‐analysis, we investigated the association of the FABP2 Ala54Thr polymorphism with insulin resistance and blood glucose. Methods We collected data on fasting blood glucose and fasting insulin, 2‐h blood glucose (2‐h BG) and 2‐h insulin (2‐h insulin), and homeostasis model assessment insulin resistance index. A dominant model was used for this meta‐analysis. Results Thirty‐one studies with 13 451 subjects were included in this meta‐analysis. The carriers of Thr54 allele have significantly higher homeostasis model assessment insulin resistance index and marginally higher fasting insulin than the non‐carriers: standardized mean difference (SMD) = 0.07, 95% confidence interval (CI, 0.02, 0.12), p = 0.007, p heterogeneity = 0.19 and SMD = 0.08, 95% CI (−0.01, 0.17), p = 0.07, p heterogeneity < 0.00001, respectively. A borderline significant association between the FABP2 Ala54Thr polymorphism and an increased 2‐h BG was also detected under the dominant model: SMD = 0.10, 95% CI (0.00, 0.20), p = 0.05, p heterogeneity = 0.09. In addition, a borderline association between this polymorphism and an increased fasting blood glucose in populations of other ethnic origins was detected under the dominant model: SMD = 0.11, 95% CI (−0.00, 0.23), p = 0.06, p heterogeneity = 0.03. Conclusions Our meta‐analysis suggests that the Thr54 allele of the FABP2 Ala54Thr is weakly associated with a higher degree of insulin resistance, higher level of fasting insulin and higher level of 2‐h BG. Our meta‐analysis also suggests a weak association between this polymorphism and an increased fasting blood glucose in populations of other ethnic origins under the dominant model. Copyright © 2010 John Wiley & Sons, Ltd.