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Prenatal exposure to cocaine: Effects on aggression in sprague‐dawley rats
Author(s) -
Johns Josephine M.,
Means Michael J.,
Woodley Bass E.,
Means Larry W.,
Zimmerman Laura I.,
McMillen Brian A.
Publication year - 1994
Publication title -
developmental psychobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 93
eISSN - 1098-2302
pISSN - 0012-1630
DOI - 10.1002/dev.420270405
Subject(s) - offspring , saline , aggression , ovariectomized rat , psychology , prenatal cocaine exposure , gestation , prenatal exposure , pregnancy , physiology , developmental psychology , endocrinology , medicine , estrogen , biology , genetics
Social/aggressive behavior in adult rat offspring (beginning at postnatal Day 180) prenatally exposed to saline, cocaine, or amfonelic acid (AFA) was examined. Pregnant rats received injections of 15 mg/kg of cocaine, or 0.9% saline twice daily, s.c., or on 2 consecutive days at 4‐day intervals, or 1.5 mg/kg amfonelic acid daily throughout gestational Days 1–20. Frequency, duration, and latency of 11 social/aggressive behaviors were recorded for two 15‐min sessions during which a smaller male intruder replaced an ovariectomized© 1994 John Wiley & Sons, Inc.