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Effect of maternal vitamin a excess on S‐100 in neonatal rat cerebellum: A preliminary study
Author(s) -
Vacca Linda,
Hutchings Donald E.
Publication year - 1977
Publication title -
developmental psychobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 93
eISSN - 1098-2302
pISSN - 0012-1630
DOI - 10.1002/dev.420100210
Subject(s) - cerebellum , vitamin , gestation , neurogenesis , medicine , endocrinology , physiology , teratology , biology , pregnancy , neuroscience , genetics
Pregnant rats were administered a teratogenic dose of vitamin A excess on Days 17 and 18 of gestation and intubation controls received the vehicle alone. Pups were sacrificed at birth or on postnatal Days 5 or 10; the cerebellum was removed, frozen, and fixed in preparation for immunohistochemical localization of the brain specific protein, S‐100. Vitamin A produced a transient delay in the appearance of S‐100 in the external granular layer which was no longer evident on Days 5 and 10. These findings corroborate autoradiographic evidence that vitamin A temporarily interferes with neurogenesis. However, the early damage results in permanent behavioral deficits in adulthood despite apparent cytochemical repair.