Premium
Genetic and ontogenetic variations in locomotor activity following treatment with scopolamine or d‐amphetamine
Author(s) -
Remington Gary,
Anisman Hymie
Publication year - 1976
Publication title -
developmental psychobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 93
eISSN - 1098-2302
pISSN - 0012-1630
DOI - 10.1002/dev.420090611
Subject(s) - amphetamine , ontogeny , open field , catecholamine , cholinergic , saline , endocrinology , inbred strain , c57bl/6 , locomotor activity , excitatory postsynaptic potential , scopolamine , medicine , inhibitory postsynaptic potential , body weight , biology , dopamine , biochemistry , gene
Highly inbred mice of 3 strains A/J, DBA/2J, and C57 BL/6J were tested in an open field at 14, 21, or 28 days of age. Ten minutes prior to testing, mice received treatment of saline, scopolamine .5 or 1.0 mg/kg of body weight, or d‐amphetamine (.5, 1.0, or 5.0 mg/kg). The d‐amphetamine 5.0 mg/kg increased activity in all strains at 14 days and 28 days of age, and at 21 days significantly increased activity in all except the C57BL/6. In contrast, increased activity with the scopolamine treatment was seen in DBA/2 at 21 days, but not in A and C57BL/6 until 28 days postnatally. The data support a caudal‐rostral gradient of brain development with the inhibitory cholinergic system developing more slowly than the excitatory catecholamine system. In addition, strain‐specific differences in activity levels are discussed in relation to the differential rates of cholinergic maturation.