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Effects of testing age and fostering experience on seizure susceptibility of rats treated prenatally with chlorpromazine
Author(s) -
Golub Mari,
Kornetsky Conan
Publication year - 1975
Publication title -
developmental psychobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 93
eISSN - 1098-2302
pISSN - 0012-1630
DOI - 10.1002/dev.420080608
Subject(s) - offspring , chlorpromazine , weaning , gestation , saline , psychology , prenatal exposure , pregnancy , seizure threshold , endocrinology , medicine , epilepsy , anticonvulsant , biology , psychiatry , genetics
Offspring of rats treated with 2 mg/kg body weight chlorpromazine (CPZ) on Days 5–8 of gestation had lower seizure thresholds than offspring of saline‐treated controls at 30, 60, 90, and 120 days of age. The CPZ‐treated offspring were also heavier than controls prior to weaning. Further analysis using cross‐fostered litters indicated that at least part of the drug effect on seizure thresholds took place before birth, although a postnatal component was also demonstrated. A striking effect of the fostering experience itself on the seizure threshold prevented conclusions about the relative importance of prenatal and postnatal influences.