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Indolethylamine‐ N ‐methyltransferase in developing rabbit lung
Author(s) -
Lin RL.,
Sargeant S.,
Narasimhachari N.
Publication year - 1974
Publication title -
developmental psychobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 93
eISSN - 1098-2302
pISSN - 0012-1630
DOI - 10.1002/dev.420070511
Subject(s) - chlorpromazine , lung , endogeny , methyltransferase , enzyme assay , enzyme , medicine , endocrinology , specific activity , chemistry , biology , andrology , biochemistry , methylation , gene
The activity of indolethylamine‐ N ‐methyltransferase (INMT) from the rabbit lung is relatively high in the newborn and increases rapidly after birth, attaining its maximum level at 15 days of age. Between the 15th and 19th postnatal days, INMT activity declines to the mature level and remains fairly constant thereafter. The decrease in the activity of the enzyme may be due to the presence of dialyzable endogenous inhibitor(s). The inhibition of the enzyme from lungs of rabbits of varying ages by S ‐adenosylhomocysteine (SAH), N, N dimethyltryptamine (DMT), and chlorpromazine (CPZ) is reported.