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Septal damage during the maturation of inhibitory responding: Effects in juvenile and adult rats
Author(s) -
Schoenfeld Thomas A.,
Hamilton Leonard W.,
Gandelman Ronald
Publication year - 1974
Publication title -
developmental psychobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 93
eISSN - 1098-2302
pISSN - 0012-1630
DOI - 10.1002/dev.420070303
Subject(s) - neurochemical , habituation , inhibitory postsynaptic potential , juvenile , lesion , psychology , neuroscience , escape response , developmental psychology , medicine , biology , psychiatry , genetics
Septal lesions were inflicted in young rats either during or after the maturation of inhibitory responding. When tested as juveniles (Day 25) or as adults, septal‐operates were significantly different from controls on 2‐way active avoidance and habituation responding, regardless of the age at which the lesion was produced. These data are in contrast with others showing that damage to subcortical structures can result in sparing of certain behavioral functions. The difference between functional sparing and functional disruption may be due to different patterns of brain projection pathways established after early lesions are produced. Neurochemical supersensitivity may also be a differentiating factor.