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The influence of stagnant hypoxia on the activity of some dehydrogenases and aminotransferases in the brain of rats during ontogenesis
Author(s) -
Jílek L.,
Janata V.,
Londonová A.,
Makč Z.,
Trojan S.,
Vorel F.
Publication year - 1973
Publication title -
developmental psychobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 93
eISSN - 1098-2302
pISSN - 0012-1630
DOI - 10.1002/dev.420060208
Subject(s) - aldolase a , hypoxia (environmental) , ontogeny , endocrinology , medicine , enzyme , enzyme assay , isozyme , ligation , biology , biochemistry , chemistry , oxygen , organic chemistry
Ligation of both common carotid arteries produces stagnant hypoxia (oligemia) in the brains of rats. The character and the intensity of the hypoxic metabolic changes depend directly on the developmental maturity of the nerve tissue, which is also true of the activity of the enzymes, LDH, aldolase, SDH, MDH, G‐6‐PDH, GDH, GPT, and GOT. In the 5‐day‐old rat after 4 hr of oligemia, enzyme activity either did not change or increased. In the 12‐day‐old rat the activity of LDH, MDH, and GPT increased and the activity of GDH, aldolase, and G‐6‐PDH decreased. At the age of 25 days and in adulthood, the activity of SDH, MDH, aldolase, and GOT decreased. The changes in enzyme activity are related to changes in proteosynthesis and appear to support the concept of a “metabolic adaptive reaction” of the immature nervous system in response to changes of the inner milieu.