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Simply produced closed‐head, focal lesions for study of repair in immature rat cerebral cortex
Author(s) -
Geller Lester M.,
Cowen David,
Wolf Abner
Publication year - 1970
Publication title -
developmental psychobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 93
eISSN - 1098-2302
pISSN - 0012-1630
DOI - 10.1002/dev.420030402
Subject(s) - lesion , cerebral cortex , cortex (anatomy) , anatomy , central nervous system , neuroscience , pathology , regeneration (biology) , medicine , biology , microbiology and biotechnology
Multiple electroconvulsive shocks consistently and rapidly produce uniform, bilaterally symmetrical lesions in the immature rat's cerebral cortex, without the incidental damage that accompanies other experimental injuries to the central nervous system. The terminal lesion, devoid of nerve cells, is a narrow, laminar band of numerous myelinated axons, unaccompanied by a glial scar. Insofar as the initially damaged area becomes occupied by nerve fibers, the healing process may be thought of as involving a regeneration. A variety of studies for which the electroshock lesions might be used is suggested.