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Temporal parameters of sensitization for audiogenic seizures in SJL/J mice
Author(s) -
Fuller John L.,
Collins Robert L.
Publication year - 1968
Publication title -
developmental psychobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 93
eISSN - 1098-2302
pISSN - 0012-1630
DOI - 10.1002/dev.420010306
Subject(s) - sensitization , stimulation , priming (agriculture) , psychology , neuroscience , medicine , audiology , anesthesia , biology , botany , germination
Susceptibility to audiogenic seizures in SJL/J mice is affected by exposure to loud sound during a sensitive age period. The effect is similar to that reported by Henry for strain C57BL/6J. In 3‐week‐old mice, priming by sound requires 5 to 20 sec; sensitization, 30 to 36 hr; convulsibility lasts for at least 21 weeks without any intervening stimulation. Repeated stimulation prior to development of convulsibility makes mice temporarily refractory to sound induction of seizures.