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Effect of LSD on the sleep cycle of the developing kitten
Author(s) -
Shimizu Akira,
Himwich Harold E.
Publication year - 1968
Publication title -
developmental psychobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 93
eISSN - 1098-2302
pISSN - 0012-1630
DOI - 10.1002/dev.420010112
Subject(s) - kitten , sleep (system call) , period (music) , anesthesia , physiology , medicine , endocrinology , zoology , biology , cats , physics , computer science , acoustics , operating system
The effects of LSD on the sleep cycle were studied in 44 kittens during the growth period of 1 to 28 days of age. Electroencephalograms, electromyograms of the posterior neck muscles, and the respiratory rhythm were recorded and gross behavior was observed. With 10 μg/kg of d ‐lysergic acid diethylamide, the per cent time of activated sleep in total sleeping time was diminished. This diminution was less marked in kittens 6 to 8 days of age or younger and became more significant in the kittens 11 to 13 days or older. With 20 μg/kg the decrease of per cent time of activated sleep was highly significant at all ages. With a larger dose, the influence of age could no longer be demonstrated. The duration of single episodes of activated sleep showed some evidence of shortening, but this effect was also not related to age.