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FKBP5 genotype and early life stress exposure predict neurobehavioral outcomes for preterm infants
Author(s) -
D'Agata Amy L.,
Walsh Stephen,
Vittner Dorothy,
Cong Xiaomei,
McGrath Jacqueline M.,
Young Erin E.
Publication year - 2017
Publication title -
developmental psychobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 93
eISSN - 1098-2302
pISSN - 0012-1630
DOI - 10.1002/dev.21507
Subject(s) - neonatal intensive care unit , fkbp5 , genotype , psychology , medicine , stress (linguistics) , clinical psychology , pediatrics , genetics , biology , glucocorticoid , gene , linguistics , philosophy , glucocorticoid receptor
PROBLEM This study evaluated the relationship between stressful early life neonatal intensive care unit (NICU) experiences, genetic variation of a stress response‐associated gene ( FKBP5 ), and neurobehavioral outcomes. METHOD The impact of genetic variation and stress experience on neurobehavioral outcomes was examined for 41 preterm infants. Statistical analyses explored the main effects of FKBP5 genotype and NICU stress experience, as well as their interaction on infant neurobehavioral development prior to discharge. RESULTS Statistical analyses demonstrated a relationship between both FKPB5 genotype and stress related to NICU care that were independently associated with neurobehavioral outcomes; indicating a main effect of genotype and a main effect of stress on neurodevelopment. Additionally, we found an interaction between the minor allele genotype and NICU stress potentially associated with less favorable developmental progress at discharge. IMPLICATIONS Evidence of genetic and environmental risk factors for neurodevelopmental impairment suggests the need for improved evidence‐based practice initiatives to protect those most vulnerable to the combination of genetic susceptibility to stress and medical fragility.