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BDNF control of adult SVZ neurogenesis
Author(s) -
Bath Kevin G.,
Akins Michael R.,
Lee Francis S.
Publication year - 2012
Publication title -
developmental psychobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 93
eISSN - 1098-2302
pISSN - 0012-1630
DOI - 10.1002/dev.20546
Subject(s) - neurogenesis , subventricular zone , neuroscience , olfactory bulb , neurotrophic factors , psychology , brain derived neurotrophic factor , neuroplasticity , biology , neural stem cell , stem cell , central nervous system , microbiology and biotechnology , biochemistry , receptor
The sensory processing of odorants is a dynamic process that requires plasticity at multiple levels. In the olfactory bulb (OB), inhibitory interneurons undergo lifelong replacement through a process known as adult neurogenesis. These newly born cells are incorporated in a learning‐dependent fashion, a process which has led some to suggest this as a primary mechanism through which the OB retains a high degree of plasticity throughout life. A continued focus of researchers in this field has been to understand the molecular mechanisms controlling adult subventricular zone (SVZ) neurogenesis and the innate functional role of these cells. Brain‐derived neurotrophic factor (BDNF) has been identified as a strong candidate molecule regulating adult OB neurogenesis. We review what is known regarding the functional role of newly born cells, highlight the role of BDNF in this process, and describe preliminary findings from our lab implicating BDNF in the process of selecting of newly born cells for survival. © 2011 Wiley Periodicals,Inc. Dev Psychobiol 54: 578–589, 2012..