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Regional white matter development in children with autism spectrum disorders
Author(s) -
Carmody Dennis P.,
Lewis Michael
Publication year - 2010
Publication title -
developmental psychobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 93
eISSN - 1098-2302
pISSN - 0012-1630
DOI - 10.1002/dev.20471
Subject(s) - autism , psychology , white matter , right hemisphere , autism spectrum disorder , lateralization of brain function , posterior parietal cortex , magnetic resonance imaging , neuroscience , audiology , cortex (anatomy) , developmental psychology , medicine , cognitive psychology , radiology
In this pilot study the severity of autism spectrum disorders (ASD) was associated with alterations in white matter development. Children with ASD and without ASD were assessed by magnetic resonance imaging (MRI) for their myelination development on a regional basis. Measures were obtained in medial frontal cortex, temporal poles, and temporo‐parietal junction in both left and right hemispheres. Children with ASD showed myelination that was greater than expected for their age in both left and right medial frontal cortex and showed myelination that was less than expected in left temporo‐parietal junction. The severity of ASD symptoms, as assessed by the Autism Diagnostic Observation Schedule—Generic, was associated more with left hemisphere alterations than right hemisphere. © 2010 Wiley Periodicals, Inc. Dev Psychobiol 52: 755–763, 2010.