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How the epigenome contributes to the development of psychiatric disorders
Author(s) -
Bredy Timothy W.,
Sun Yi E.,
Kobor Michael S.
Publication year - 2010
Publication title -
developmental psychobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 93
eISSN - 1098-2302
pISSN - 0012-1630
DOI - 10.1002/dev.20424
Subject(s) - epigenome , epigenetics , dna methylation , neuroscience , epigenesis , psychological repression , biology , psychology , genetics , gene , gene expression
Epigenetics commonly refers to the developmental process by which cellular traits are established and inherited without a change in DNA sequence. These mechanisms of cellular memory also orchestrate gene expression in the adult brain and recent evidence suggests that the “epigenome” represents a critical interface between environmental signals, activation, repression and maintenance of genomic responses, and persistent behavior. We here review the current state of knowledge regarding the contribution of the epigenome toward the development of psychiatric disorders. © 2010 Wiley Periodicals, Inc. Dev Psychobiol 52: 331–342, 2010.