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Sexually dimorphic effects of postnatal treatment on the development of activity‐based anorexia in adolescent and adult rats
Author(s) -
Hancock Stephanie D.,
Grant Virginia L.
Publication year - 2009
Publication title -
developmental psychobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 93
eISSN - 1098-2302
pISSN - 0012-1630
DOI - 10.1002/dev.20403
Subject(s) - anorexia nervosa , anorexia , psychology , endocrinology , medicine , animal model , affect (linguistics) , physiology , developmental psychology , eating disorders , psychiatry , communication
Hyperactivity of the hypothalamic–pituitary–adrenal (HPA) axis is a marked feature of anorexia nervosa. Using a modified version of the activity‐based animal model of anorexia nervosa, we examine whether factors known to affect HPA axis activity influence the development of activity‐based anorexia (ABA). Male and female rats were subjected to maternal separation or handling procedures during the first two postnatal weeks and tested in a mild version of the ABA paradigm, comprised of 2‐hr daily running wheel access followed by 1‐hr food access, either in adolescence or adulthood. Compared to handled females, maternally separated females demonstrated greater increases in wheel running and a more pronounced running‐induced suppression of food intake during adolescence, but not in adulthood. In contrast, it was only in adulthood that wheel running produced more prolonged anorexic effects in maternally separated than in handled males. These findings highlight the interplay between early postnatal treatment, sex of the animal, and developmental age on running, food intake, and rate of body weight loss in a mild version of the ABA paradigm. © 2009 Wiley Periodicals, Inc. Dev Psychobiol 51: 679–695, 2009.