Open AccessA novel, simple, and dedicated device for endoscopic mucosal defect closure
Author(s) -
Nose Yohei,
Takizawa Kohei,
Shiotsuki Kazuo,
Yamaguchi Tsuyoshi,
Agatsuma Masaomi,
Nitta Shun,
Yamashita Kotaro,
Saito Takuro,
Tanaka Koji,
Yamamoto Kazuyoshi,
Makino Tomoki,
Takahashi Tsuyoshi,
Kurokawa Yukinori,
Eguchi Hidetoshi,
Doki Yuichiro,
Nakajima Kiyokazu
Publication year - 2022
Publication title -
den open
Language(s) - English
Resource type - Journals
ISSN - 2692-4609
DOI - 10.1002/deo2.98
Subject(s) - clips , endoscopic submucosal dissection , thread (computing) , computer science , closing (real estate) , surgery , tube (container) , usability , materials science , biomedical engineering , medicine , operating system , composite material , political science , law
Objectives Endoscopic submucosal dissection (ESD) has become popular, but complications such as postoperative bleeding remain an issue. Although some methods of closing a mucosal defect with a snare and clips have been reported to be effective and safe, the snare is not a dedicated device, and the procedure is difficult and time‐consuming. We aimed to find an alternative method for defect closure after ESD by developing a dedicated device. Methods We have improved five prototypes. The load on the stopper when starting to tighten and loosen a loop and the maximum load on the stopper and the movement distance of the thread when sliding the stopper were measured five times for each prototype. With the 5th prototype, we finalized the design and named it FLEXLOOP. Additionally, the material and shape of the outer tube were improved. Then, the usability of FLEXLOOP was evaluated in pigs. The operation time for closing mucosal defects with the snare or FLEXLOOP was measured five times. Results We made FLEXLOOP, which had a lower load when sliding and a higher load when loosening than the snare. The improvement of the outer tube significantly reduced the load on the sheath when sliding it. We confirmed the feasibility of mucosal defect closure with FLEXLOOP in pigs. The median operation time was 563 s (range 340–679 s) with the snare and 355 s (range 303–455 s) with FLEXLOOP ( p = 0.047). Conclusions FLEXLOOP can be a promising option for defect closure after ESD.