Open AccessThe natural history of sporadic non‐ampullary duodenal epithelial tumors: Can we wait and see?
Author(s) -
Sakaguchi Yoshiki,
Tsuji Yosuke,
Ushiku Tetsuo,
Kubota Dai,
Sato Junichi,
Obata Miho,
Cho Rina,
Nagao Sayaka,
Sakuma Nobuyuki,
Tamura Naoki,
Miura Yuko,
Fukagawa Kazushi,
Ohki Daisuke,
Mizutani Hiroya,
Takeuchi Chihiro,
Takahashi Yu,
Minatsuki Chihiro,
Niimi Keiko,
Yamamichi Nobutake,
Koike Kazuhiko
Publication year - 2021
Publication title -
den open
Language(s) - English
Resource type - Journals
ISSN - 2692-4609
DOI - 10.1002/deo2.9
Subject(s) - natural history , natural (archaeology) , medicine , gastroenterology , history , archaeology
Objectives The natural history of sporadic non‐ampullary duodenal epithelial tumors (SNADETs) is poorly documented. The aim of this study was to evaluate the history of SNADETs in patients where immediate resection could not be performed. Methods This is a single‐center retrospective study of 86 consecutive cases of SNADETs who did not undergo immediate resection and were followed‐up with upper gastrointestinal endoscopy for more than 6 months. Results During a follow‐up period of 36.8 (6.0–613.0) months, macroscopic progression was admitted in eight (9.3%). Of these, the final histology in four was adenocarcinoma, and three cases demonstrated submucosal invasion. Rates of macroscopic progression at 150 months after detection were 11.1%, 16.7%, and 30.0% for SNADETs <5 mm, <10 mm, and ≥10 mm, respectively. Conclusion The overall risk of SNADETs progressing to invasive cancer is low. However, changes in macroscopic size or shape of SNADETs signify a high risk of progression to invasive cancer.