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D 2 and 5‐HT 2 modulation of psychostimulant‐induced facilitation of brain stimulation reward
Author(s) -
Tsibulsky Vladimir,
Dashevsky Boris,
Frank Robert A.
Publication year - 1995
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430340307
Subject(s) - eticlopride , serotonergic , amphetamine , brain stimulation reward , antagonist , stimulation , dopaminergic , psychology , facilitation , neuroscience , pharmacology , dopamine , serotonin , sch 23390 , medicine , receptor , nucleus accumbens
Previous research in our laboratory demonstrated that mixed D 2 /5‐HT 2 antagonists (i.e., MDL 28, 133A, and risperidone) attenuate both amphetamine and cocaine‐induced facilitation of brain stimulation reward. The relative contributions of dopaminergic and serotonergic antagonism to these effects was assessed in the present study. Factorial combinations of the D 2 antagonist eticlopride and the 5‐HT 2 antagonist MDL 100,907 were evaluated for their ability to reverse both cocaine and amphetamine‐induced facilitation of brain stimulation reward. Eticlopride significantly reduced the effects of both amphetamine and cocaine, while MDL 100,907 had no effect on self‐stimulation thresholds when administered alone, or in combination with eticlopride. Thus, no evidence for serotonergic regulation of the euphoric effects of psychostimulants was obtained. © 1995 Wiley‐Liss, Inc.