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Effects of GS 386, a novel dihydroisoquinoline compound, on rabbit atrial myocytes and rat aorta
Author(s) -
Chang Ki Churl,
Park Choon Ok,
Hong Seong Geun
Publication year - 1994
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430330409
Subject(s) - phenylephrine , aorta , vasodilation , medicine , chemistry , myocyte , patch clamp , biophysics , endocrinology , anatomy , cardiology , electrophysiology , biology , blood pressure
Abstract The effects of GS 386, a novel benzylisoquinoline derivative, on Ca 2+ current and vasodilatation were investigated using the single rabbit atrial myocyte and rat thoracic aorta preparations. In rabbit myocytes, the Ca 2+ current was recorded during various depolarizations for 200 ms from a holding potential of −40 mV using the whole patch‐clamp technique. Superfusion of GS 386 led to a reduction of the Ca 2+ current amplitude concentration‐dependently, in which the IC 50 value was 0.25 μM. However, the dependence of the Ca 2+ current on the membrane potential was not altered by GS 386. In rat aorta, GS 386 inhibited high K + ‐induced contractions more strongly than that induced by phenylephrine. These results indicate that GS 386 has Ca 2+ antagonistic actions in rat aorta and rabbit heart. © 1994 Wiley‐Liss, Inc.