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In vivo agonist properties of 7‐hydroxy‐N,N‐di‐n‐propyl‐2‐aminotetralin, a dopamine D 3 ‐selective receptor ligand
Author(s) -
McElroy John,
Zeller Kim,
Amy Kelly,
Ward Kathryn,
Cawley James,
Mazzola Amie,
Keim William,
Rohrbach Kenneth
Publication year - 1993
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430300409
Subject(s) - agonist , endogenous agonist , chemistry , apomorphine , dopamine receptor d3 , dopamine , dopamine receptor , pharmacology , dopamine receptor d2 , catalepsy , dopamine agonist , medicine , endocrinology , in vivo , dopamine receptor d1 , quinpirole , receptor , biology , biochemistry , haloperidol , microbiology and biotechnology
The selective dopamine D 3 receptor ligand 7‐hydroxy‐N,N‐di‐n‐propyl‐2‐aminotetralin (7‐OH‐DPAT) produced stereotypical sniffing and climbing, increased locomotor activity, and caused 6‐hydroxydopamine‐lesioned animals to rotate in a contralateral direction, behavioral effects highly predictive of dopamine agonist activity. In contrast, 7‐OH‐DPAT was inactive in the conditioned avoidance response, catalepsy, and anti‐apomorphine test, animal models highly predictive of dopamine antagonist activity. These results indicate that 7‐OH‐DPAT is an agonist at dopamine receptors in vivo. © 1993 wiley‐Liss, Inc.