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Interaction of berbamine and chloroquine or artemisinin against chloroquine‐sensitive and ‐resistant plasmodium falciparum in vitro
Author(s) -
Ye Zuguang,
Van Dyke Knox,
Yang Baizhen
Publication year - 1993
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430300405
Subject(s) - artemisinin , plasmodium falciparum , chloroquine , pharmacology , malaria , in vitro , combination therapy , parasite hosting , drug , biology , chemistry , immunology , biochemistry , world wide web , computer science
Antimalarial activity of berbamine (BB), alone or in combination with chloroquine (CQ) or artemisinin (qinghaosu, QHS), was studied using CQ‐sensitive and ‐resistant strains of Plasmodium falciparum in vitro. BB was found to have antimalarial effects with IC 50 values of 603 and 359 nM, respectively, for the drug‐sensitive and ‐resistant strains of P. falciparum , indicating that BB exhibited some selective antimalarial activity against the drug‐resistant parasite. Its antimalarial efficacy and selectivity appeared to be less than that of tetrandrine (TT), however, when BB was combined with CQ, an antagonistic interaction was found against the CQ‐sensitive parasite, while a potentiating antimalarial action was observed with the CQ‐resistant parasite. When BB was tested in combination with QHS, a complex interaction was found—one was additive for the CQ‐sensitive parasite and the other was potentiating for the CQ‐resistant parasite. The above data suggested that the BB combination with either CQ or QHS is a promising candidate for an antimalarial remedy to treat at least CQ‐resistant falciparum parasites which cause malaria. © 1993 wiley‐Liss, Inc.