Premium
Structure, synthesis, and antitumor activity of the hydrolysis product of the antitumor agent carmethizole
Author(s) -
Anderson Wayne K.,
Houston D. Michael,
Jarosinski Mark A.,
Kinder Frederick R.,
Kode Rao N.,
Van Roey Patrick,
Salerno Jeffrey M.
Publication year - 1993
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430300306
Subject(s) - chemistry , hydrolysis , biological activity , toxicity , stereochemistry , reactivity (psychology) , chemical synthesis , drug , structure–activity relationship , pharmacology , product (mathematics) , in vitro , combinatorial chemistry , biochemistry , organic chemistry , medicine , alternative medicine , geometry , mathematics , pathology
The two isomeric monocarbamates, 2b and 2c, related to the antitumor drug carmethizole (1) were synthesized and the structure of the carmethizole hydrolysis product, 2b, was established by X‐ray crystallography. The chemical reactivity, toxicity, and antitumor activity of the two monocarbamates, 2b and 2c, were compared with 1. © 1993 wiley‐Liss, Inc.