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Chronic theophylline prolongs the refractory period in amygdala‐kindled rats
Author(s) -
Kleinsorge Robert J.,
Bowers Lakeisha M.,
Jarvis Michael F.,
Berman Robert F.
Publication year - 1993
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430290406
Subject(s) - kindling , theophylline , adenosine , stimulation , amygdala , adenosine receptor , medicine , hippocampus , refractory period , endocrinology , chemistry , convulsion , epilepsy , receptor , pharmacology , neuroscience , psychology , agonist
The effects of chronic theophylline treatment on brain adenosine A 1 receptors and amygdala‐kindled seizures were examined in rats. The repeated administration of theophylline 417 μmoles/kg/day i.p. (75 mg/kg/day) for 14 days resulted in a significant increase in 1 nM [ 3 H]cyclohexyladenosine binding to adenosine A 1 receptors in thalamus, hippocampus, and cerebellum. This chronic theophylline treatment was shown to significantly prolong the immediate postseizure refractory period (defined as sensitivity to a subsequent kindling stimulation) while both the severity and duration of an initial kindled seizure was not affected. These findings indicate that the postseizure refractory period can be influenced by the brain adenosine system, and implicate adenosine as an important neuromodulator of the patterning of seizure episodes. © 1993 Wiley‐Liss, Inc.