Premium
Mechanism of the effector function of adenosine in asthma and rhintis
Author(s) -
Crimi Nunzio,
Polosa Riccardo,
Mistretta Antonino
Publication year - 1993
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430280325
Subject(s) - adenosine , autacoid , histamine , mechanism (biology) , effector , provocation test , asthma , nucleoside , immunology , purine , medicine , pharmacology , adenosine receptor , theophylline , pathophysiology , receptor , chemistry , endocrinology , biochemistry , agonist , pathology , enzyme , alternative medicine , epistemology , philosophy
Adenosine, a purine nucleoside which may be formed following immunological activation, may act as an autacoid by modulating the function of a variety of cells. In asthmatic and rhinitic subjects, but not in normals, exposure to adenosine causes marked responses, which are markedly reduced by pretreatment with histamine‐H1 receptor antagonists. Although the mechanism by which adenosine induces changes in the function of the lower and upper airways are not clear this form of provocation of the airways may serve as a convenient tool in investigating the characteristic pathophysiological changer of asthma and rhinitis. © 1993 Wiley‐Liss, Inc.