Premium
Adenosine and cerebral microcirculation
Author(s) -
Kuschinsky Wolfgang
Publication year - 1993
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430280323
Subject(s) - adenosine , microcirculation , cerebral blood flow , vasodilation , ischemia , neuroscience , hypoxia (environmental) , feed forward , medicine , endocrinology , chemistry , biology , oxygen , organic chemistry , control engineering , engineering
Adenosine participates in the coupling of function to blood flow in the brain. With regard to the 2 mechanisms of coupling, the feedforward and feedback mechanisms, adenosine plays an important role in feedback regulation. Whereas the feedforward mechanism is based on the fast release of K + form the cell, which induces an immediate vasodilatory response of cerebral vessels, feedback regulation appears to yield a long‐term adjustment of blood flow to the metabolic demands of the brain tissue. This holds for physiological conditions and even more for pathophysiological conditions, such as hypoxia and ischemia. © 1993 Wiley‐Liss, Inc.