Adenosine and cerebral microcirculation | Zendy

Kuschinsky Wolfgang | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Adenosine and cerebral microcirculation

Author(s) -

Kuschinsky Wolfgang

Publication year - 1993

Publication title -

drug development research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.582

H-Index - 60

eISSN - 1098-2299

pISSN - 0272-4391

DOI - 10.1002/ddr.430280323

Subject(s) - adenosine , microcirculation , cerebral blood flow , vasodilation , ischemia , neuroscience , hypoxia (environmental) , feed forward , medicine , endocrinology , chemistry , biology , oxygen , organic chemistry , control engineering , engineering

Adenosine participates in the coupling of function to blood flow in the brain. With regard to the 2 mechanisms of coupling, the feedforward and feedback mechanisms, adenosine plays an important role in feedback regulation. Whereas the feedforward mechanism is based on the fast release of K + form the cell, which induces an immediate vasodilatory response of cerebral vessels, feedback regulation appears to yield a long‐term adjustment of blood flow to the metabolic demands of the brain tissue. This holds for physiological conditions and even more for pathophysiological conditions, such as hypoxia and ischemia. © 1993 Wiley‐Liss, Inc.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research