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Hypoxia, endothelium, and purines
Author(s) -
Burnstock Geoffrey
Publication year - 1993
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430280320
Subject(s) - hypoxia (environmental) , vasodilation , nitric oxide , purine metabolism , purine , endothelium , ischemia , chemistry , purinergic receptor , adenosine , pharmacology , endocrinology , medicine , biochemistry , biology , oxygen , enzyme , organic chemistry
The article focuses on the events involving purine nucleotides and nucleosides during the initial responses of the cerebral vascular bed to ischaemia. In particular, the role of ATP released from endothelial cells which acts on P 2Y ‐purinoceptors, leading to production of nitric oxide and subsequent vasodilatation, will be considered. A relation between these events and the involvement of purines in the longer term degenerative consequences of ischaemia seems unlikely. © 1993 Wiley‐Liss, Inc.