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Adenosine system in the heart
Author(s) -
Belardinelli Luiz
Publication year - 1993
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430280313
Subject(s) - adenosine , adenosine receptor , adenosine a1 receptor , nucleoside , receptor , chemistry , pharmacology , mechanism of action , adenosine a3 receptor , medicine , vasodilation , endocrinology , biology , biochemistry , in vitro , agonist
The adenosine system in the heart consists of three components : (1) a mechanism formation, (2) a receptor‐effector coupling system, and (3) a mechanism for degradation. Selective pharmacological modification of this system with drug such as nucleoside uptake inhibitors osine. The action of adenosine in the heart are mediated by specific cell surface receptors of at least two subtypes. The A 1 receptor subtype mediates the actions of adenosine that decrease O 2 consumption (e.g, slowing of heart rate), whereas the A 2 receptor subtype mediates the well‐known coronary vasodilatory effects of adenosine and thereby increases O 2 supply. Adenosine formation is increased when O 2 demand exceeds O 2 supply. Thus, in the heart adenosine may serve as a negative‐feedback signal to adjust myocardial balance between O 2 supply and consumption. In this brief review we describe the cardiovascular effects of adenosine, its mechanism(s) of action, and metabolism. © 1993 Wiley‐Liss, Inc.