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Microgram doses of chlordiazepoxide and diazepam do not increase punished responding in the rat
Author(s) -
Pollard Gerald T.,
Howard James L.
Publication year - 1992
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430270411
Subject(s) - chlordiazepoxide , diazepam , microgram , anxiolytic , pharmacology , dose dependence , chemistry , medicine , biochemistry , receptor , in vitro
Microgram doses of chlordiazepoxide and diazepam injected intraperitoneally (i.p.) have been reported to change rodent behavior, notably in two observational procedures that predict anxiolysis. We tested half‐log doses from 0.03 to 10 mg/kg in the Geller‐Seifter conflict preparation in the rat. Only doses in the milligram range showed any tendency to increase punished responding. The results do not support the hypothesis that microgram doses might be anxiolytic. © 1992 Wiley‐Liss, Inc.