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Protective effects of zinc L‐carnosine (Z‐103) on reserpine‐induced gastric ulceration in rats
Author(s) -
Cho C. H.
Publication year - 1992
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430270107
Subject(s) - reserpine , degranulation , mast cell , gastric mucosa , medicine , pharmacology , endocrinology , chemistry , stomach , immunology , receptor
The present study examined the gastric protective effects of zinc L‐carnosine (Z‐103) in reserpinized rats. We also studied whether this antiulcer effect is related to the preservation of mast cells degranulation in the glandular mucosa. Reserpine administration (5 mg/kg, intraperitoneally [i.p.]) produced severe hemorrhagic glandular ulcers which were accompained with a marked decrease in mucosal mast cell counts. The severity of ulcers and mast cell degranulation were reduced by Z‐103 when given orally 30 min before and 6 hr after reserpinization. However, this protection was not observed when the drug was administered as a single dose 30 min beforehand. The present findings extended the antiulcer action of Z‐103 from stress‐ and ethanol‐induced gastric damage to those on reserpine‐provoked gastric ulcers. It also indicates that the protective action on reserpine ulceration is likely to be due to the stabilization on mast cell membrane in the glandular mucosa. © 1992 Wiley‐Liss, Inc.