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Long‐term choline alfoscerate treatment counteracts age‐dependent structural changes in the rat hippocampus
Author(s) -
Bronzetti Elena,
Collier Wade L.,
Felici Laura,
Zaccheo Damiano,
Amenta Francesco
Publication year - 1992
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430260408
Subject(s) - dentate gyrus , hippocampus , hippocampal formation , choline , medicine , endocrinology , chemistry
Abstract Long‐term choline alfoscerate (αGFC) treatment counteracts age‐dependent structural changes in the hippocampus of Sprague‐Dawley rats. Animals treated with a daily dose of 100 mg/kg αGFC from 18 to 24 months of age had more cells in the CA‐1 to CA‐3 fields and in the dentate gyrus compared to age‐matched cohorts. The density of silver‐gold stained fibers within the stratum oriens of the CA‐1 to CA‐2 fields was greater in rats treated with αGFC than in age‐matched controls. The ramifications of these findings are discussed. © 1992 Wiley‐Liss, Inc.