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Effects of L‐alpha‐glycerylphosphorylcholine on the EEG power spectrum in the rat
Author(s) -
Lacomba Corrado,
Cagiano Raffaele,
Maci Oronzo,
Valerio Jaqueline,
Cuomo Vincenzo
Publication year - 1992
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430260109
Subject(s) - alpha (finance) , acetylcholine , electroencephalography , chemistry , beta (programming language) , pharmacology , medicine , endocrinology , psychology , neuroscience , developmental psychology , construct validity , computer science , programming language , psychometrics
The effects of L‐alpha‐glycerylphosphorylcholine (alpha‐GPC), a putative acetylcholine precursor, on the EEG power spetrum in rats were investigated. The results show that the oral administration of alpha‐GPC (100–300–600 mg/kg) induced a significant decrease in absolute spectral energy in the delta frequency band. A significant increase in absolute spectral energy in the beta frequency band was elicited by alpha‐GPC at dose levels of 100 and 300 mg/kg, while the administration of a higher dose (600 mg/kg) of this compound resulted in the loss of response (bell‐shaped dose‐response curve). No significant changes in the EEG power spectrum were found in rats treated with phosphatidylcholine (PC). The present data, suggesting that the electrocorticographic (ECoG) activation elicited by alpha‐GPC may be correlated with its stimulatory effect on brain acetylcholine release, further extend the pharmacological profile of this new cognition enhancer. © 1992 Wiley‐Liss, Inc.