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Effects of p ‐chloroamphetamine and a side‐chain monofluorinated analogue on levels of indoles in rat brain
Author(s) -
Owen Michael L. S.,
Baker Glen B.,
Coutts Ronald T.,
Dewhurst William G.
Publication year - 1991
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430240112
Subject(s) - p chloroamphetamine , chemistry , antidepressant , neurotoxicity , tryptophan , serotonin , pharmacology , medicine , endocrinology , toxicity , biochemistry , hippocampus , serotonergic , amino acid , receptor , organic chemistry
Levels of tryptophan (Trp), 5‐hydroxytryptamine (5‐HT), and 5‐hydroxyindole‐3‐acetic acid (5‐HIAA) in rat brain were measured at 1, 2, 4, and 24 hr after intraperitoneal administration of p ‐chloroamphetamine (pCA) (0.03 mmol/kg) or of p ‐cloro‐α‐fluoromethylphenylethylamine (fluoro‐p‐chloroamphetamine; FpCA) (0.05 or 0.10 mmol/kg). FpCA is less potent than pCA at producing depletions of 5‐HT and elevations of Trp, and the effects with FpCA are shorter‐lasting. pCA has been reported to possess good antidepressant properties but was withdrawn from clinical studies because of reported neurotoxicity to 5‐HT systems in rat brain. The less potent effects of FpCA on 5‐HT and 5‐HIAA reduction shown here suggest that further research on this analogue as a potential antidepressant is warranted.