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Long‐term follow‐up treatment with sabeluzole in elderly patients with pronounced memory problems of unknown origin
Author(s) -
Clincke Gilbert,
Tritsmans Luc,
Peelmans Boudewijn
Publication year - 1991
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430230403
Subject(s) - recall , task (project management) , term (time) , audiology , psychology , cued recall , free recall , fluency , verbal fluency test , recall test , cognitive psychology , medicine , developmental psychology , neuropsychology , cognition , neuroscience , physics , mathematics education , management , quantum mechanics , economics
In an open follow‐up study, 31 elderly patients with real memory problems of unknown origin were treated for at least 10 months with sabeluzole 10 mg b.i.d. Not only were the same improvements seen as in the preceding double‐blind trial on the cued recall task (CRT) and the word fluency test (WF), but additionally, significantly better results were obtained for the selective reminding procedure after this long‐term treatment: all quantitative (total recall, long‐term storage [LTS], long‐term retrieval [LTR], consistent long‐term retrieval [cLTR]) and qualitative (LTR/total recall, cLTR/total recall) parameters improved in this task. The objective effects were again accompanied by a subjective improvement as reported by the patients and their physician.