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Subcortical arteriosclerotic encephalopathy (Binswanger's disease): Clinical observations and therapeutic implications
Author(s) -
Bogucki Andrzej,
Prusiński Antoni,
Szymańska Róźa,
Lorenc Józefa
Publication year - 1991
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430230305
Subject(s) - arteriosclerosis , medicine , cholesterol , cardiology , cerebral atherosclerosis , apolipoprotein b , disease , encephalopathy , dementia , vascular disease , endocrinology , pathology
Subcortical arteriosclerotic encephalopathy (SAE), or Binswanger's disease, is one of the forms of vascular dementia. In SAE arteriosclerotic changes affect subcortical arteries and arteroles. Atherosclerosis of large cerebral arteries is common among SAE patients. As dyslipoproteinemias are risk factors for atherosclerosis we studied blood lipids and lipoproteins in patients with clinical diagnosis of SAE. In 11 patients diagnosis of the disease was established on the basis of CT scans and clinical course consistent with SAE. In the studied group a tendency to increased total cholesterol and apolipoprotein B and to decreased HDL cholesterol (HDL‐CH) were found. The levels of LDL cholesterol (LDL‐CH) and the CH/HDL‐CH and HDL phospholipides/HDL‐CH ratios were significantly higher in SAE patients when compared to controls.