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Hepatoprotective activity of picroliv, the active principle of Picrorhiza kurrooa , on rat hepatocytes against paracetamol toxicity
Author(s) -
Visen P. K. S.,
Shukla Binduja,
Patnaik G. K.,
Kaul Surabhi,
Kapoor N. K.,
Dhawan B. N.
Publication year - 1991
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430220303
Subject(s) - hepatoprotection , alkaline phosphatase , chemistry , pharmacology , hepatocyte , transaminase , toxicity , biochemistry , in vivo , ex vivo , liver toxicity , enzyme , in vitro , medicine , biology , glutathione , microbiology and biotechnology , organic chemistry
Picroliv, the active principle an iridoid glycoside mixture isolated from the plant Picrorhiza kurrooa , showed dose‐dependent (0.75–12 mg/kg × 7 days) protective activity on isolated hepatocytes (ex vivo) against paracetamol‐induced hepatic damage in rats. It increased the percent viability of the hepatocytes. Picroliv also restored the normal values of enzyme (glutamic oxaloacetic transaminase [GOT], glutamic‐pyruvic transaminase [GPT], and alkaline phosphatase) both in the isolated hepatocyte suspension as well as in the serum. Picroliv was found to be more potent than silymarin, a known hepatoprotective agent.