Premium
Magnesium aspartate HCl and magnesium chloride hexahydrate OROS: Comparative absorption of magnesium in dogs
Author(s) -
Coram Willie Mae,
Foster Clarence E.,
Senft Carl J.,
Douglas Frank L.,
Weiss George B.
Publication year - 1990
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430210404
Subject(s) - magnesium , chemistry , excretion , oral administration , absorption (acoustics) , urinary system , urine , magnesium acetate , pharmacokinetics , endocrinology , medicine , biochemistry , physics , organic chemistry , acoustics
The absorption of magnesium (Mg 2+ ) was measured after oral administration to dogs as a sustained‐release MgCl 2 ·6H 2 O OROS formulation (MgCl 2 ) or as magnesium aspartate hydrochloride (MAH). The compounds and their respective placebos were given at five 90 min intervals in 7.5 mEq doses (sequential protocol) or in ascending daily doses of 7.5, 22.5, and 45 mEq over 3 days (ascending protocol). Urinary excretion of Mg 2+ over 24 hr was significantly increased compared to placebo in the dogs given sequential MgCl 2 or MAH and was two‐fold greater in the MgCl 2 ‐treated group compared to the MAH group. Plasma Mg 2+ increased more rapidly in the MgCl 2 ‐treated dogs but was identical in both groups 1 hr after the fifth sequential dose. Ascending daily doses of MgCl 2 and MAH increased urinary Mg 2+ and plasma Mg 2+ maximally 2–4 hr after each dose; the magnitude of the effect was dose‐dependent in the MgCl 2 group. Sequential doses of MgCl 2 or MAH increased urinary Ca 2++ excretion by 1.06 and 1 mEq/24 hr respectively while the ascending doses of 22.5 and 45 mEq MgCl 2 produced significantly greater urinary Ca 2+ excretion than the same doses of MAH. Plasma Ca 2+ was not changed by either Mg 2+ salt in either dose regimen. The data indicate that Mg 2+ is readily absorbed after oral administration in the form of either MgCl 2 or MAH, but MgCl 2 is absorbed more rapidly. Increased urinary excretion of Ca 2+ after MgCl 2 or MAH may reflect a displacement of tissue Ca 2+ by Mg 2+ .